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SKU: 46111775002 · From elitechmx.com

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Description

Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections

VD deficiency results in neuronal cell death by inducing neuroexcitatory toxicity via triggering a sudden increase in cytoplasmic Ca 2+ , elevating ROS generation, and inducing mitochondrial dysfunction

Radtke KK, Coles LD, Mishra U, Orchard PJ, Holmay M, Cloyd JC

Second, S-nitrosylation of Heat Shock Cognate 70 kDa protein (HSC70) at a critical cysteine in its ATP-binding domain enables the co-chaperone Csp to enhance F508del-CFTR folding and stability (Zaman et al., 2006)